• Drug resistance development often involves structurally un r

  2025-02-14

  

  Drug resistance development often involves structurally un-related drugs and, specifically both conventional and targeted agents. IGROV-1/Pt1 antioxidant are characterized by resistance to cisplatin and reduced sensitivity to inhibitors of EGF-R and MEK, the up-stream activator of ERK1/2, associate

• br Materials and methods br Results br Discussion

  2025-02-14

  

  Materials and methods Results Discussion Human MutL-family complexes (MutLα: MLH1-PMS2, MutLβ:MLH1-PMS1, MutLγ:MLH1-MLH3) exhibit multiple molecular activities including DNA binding, DNA cleavage, ATP binding and hydrolysis [43]. In our recent study, we have uncovered an important function

• AP activity is increased by MAP

  2025-02-14

  

  AP-1 activity is increased by MAP kinase stimulation in different cell types (Whitmarsh and Davis, 1996), while MKP-1, the enzyme that catalyzes the dephosphorylation and inactivation of MAP kinases in the nucleus, inhibits AP-1 (Rössler et al., 2008, Rössler and Thiel, 2009, Mayer et al., 2011, Thi

• Tetracyclines constitute one of the most important antibioti

  2025-02-14

  

  Tetracyclines constitute one of the most important antibiotic groups used as veterinary and human medicine and as feed additives in the agricultural sector (Li et al., 2011a, Simon, 2005). Annual worldwide production of tetracyclines is estimated to be in the thousands of tons (Michalova et al., 200

• While we chose to divide our etiologies into

  2025-02-14

  

  While we chose to divide our etiologies into three categories, it should be noted that such division has certain limitations. Even though URIs and the common cold are considered mainly viral in origin and rhinosinusitis mainly bacterial in origin,26, 27 there is considerable overlap between these co

• Di ethylhexyl phthalate DEHP is one of the most widely

  2025-02-13

  

  Di-(2-ethylhexyl) phthalate (DEHP) is one of the most widely used environmental chemicals in the production of polyvinyl chloride. After dna repair pathways into human body, DEHP can be converted to the metabolite mono-ethylhexyl phthalate (MEHP), which has higher toxicity than DEHP and can influenc

• br Materials and methods br Results

  2025-02-13

  

  Materials and methods Results Discussion In this study, we have demonstrated that the adiponectin system (genes and proteins) is present in the porcine endometrium (epithelial glandular cells, luminal epithelial sphingosine kinase and stromal cells) and myometrium (longitudinal and circula

• A highly attenuated B pertussis strain

  2025-02-13

  

  A highly attenuated B. pertussis strain, named BPZE1, has recently been described [10]. It produces enzymatically inactive pertussis toxin (PT), no dermonecrotic toxin and only trace amounts of tracheal cytotoxin. Markedly reduced lung pathology was observed in mice intranasally (i.n.) infected with

• br Acknowledgements MC and PD were funded by

  2025-02-13

  

  Acknowledgements MC and PD were funded by the Michael J Fox Foundation (Grant ID 9969). We would like to thank Pierluigi Saba, Francesco Traccis and Barbara Tuveri for their technical assistance. Introduction In the prostate, androgens play a crucial role in normal, BPH and cancerous growth b

• br The Molecular Machinery of Autophagy and Regulation by

  2025-02-13

  

  The Molecular Machinery of Autophagy and Regulation by Sphingolipids Sphingolipid-Mediated Autophagy in Cancer: Dr. Jekyll and Mr. Hyde Autophagy is an evolutionarily conserved stress response that typically promotes survival and antagonizes apoptosis. However, excessive autophagy was found to

• In addition understanding the relationship between human met

  2025-02-12

  

  In addition, understanding the relationship between human metabolic processes and dietary antioxidant intake would provide opportunities for altering the diet to improve health (Prior, 2015). Prior et al. (2007) emphasized that excess reactive oxygen species, which occurred during the metabolism of

• br MADS box proteins in plants a flourishing

  2025-02-12

  

  MADS box proteins in plants, a flourishing family In contrast to animals, homeotic genes in plants do not code for homeodomain-containing proteins, but rather, in almost all cases, for MADS domain proteins. The sequencing of the genome of Arabidopsis thaliana revealed more than 100 putative MADS

• br HIF Blockade in AA Therapy In

  2025-02-12

  

  HIF-α Blockade in AA Therapy In lieu of the evidence supporting a central role for HIF-α signaling in tumor angiogenesis and CC pathobiology, significant efforts have focused on the discovery of small-molecule HIF-α inhibitors (for exhaustive compendia, see [28,44,45]). In brief, inhibitors vary

• Immunohistochemistry Hearts from young and

  2025-02-12

  

  Immunohistochemistry: Hearts from young and aged mice were collected at the indicated times, fixed overnight in 10% formalin, and embedded in paraffin. Serial 5-μm heart sections from each group were analyzed. Samples were stained with H&E for routine histologic examination. Immunohistochemical stai

• The AMP Activated Protein Kinase AMPK has

  2025-02-12

  

  The 5′AMP-Activated Protein Kinase (AMPK) has evolved as an important cellular sensor of reduced energy status that can subsequently phosphorylate its target proteins, slowing the rates of key biosynthetic processes and promoting energy producing pathways; for these reasons AMPK has been proposed as

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