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Most studies on d penicillamine induced MG were
2024-07-18
Most studies on d-penicillamine-induced MG were performed before the discovery that some MG patients have anti-MuSK antibodies. After the identification of the present case, we retrospectively tested the stored frozen sera of ten earlier identified d-penicillamine MG patients with anti-AChR UNC2025
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A correlation analysis was performed to investigate a possib
2024-07-18
A correlation analysis was performed to investigate a possible relationship between serum resistin levels and MG-ADL. We observed a significant relationship between serum resistin levels and MG-ADL scores in AChR-GMG-positive cases (r=0.285, p=0.032; Fig. 1C). There were also significant correlation
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The AAP s policy statement on childhood adversities
2024-07-17
The AAP’s policy statement on childhood adversities is a call to the pediatric palmitoylethanolamide reviews to apply the knowledge toward developmental screening in clinical practice. It is a movement to increase education around childhood adversity as a public health crisis and to build trauma-in
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Evidences have suggested that impairment of CK
2024-07-17
Evidences have suggested that impairment of CK activity contributes to inhibition of Na+, K+-ATPase and H+-ATPase activities during infectious diseases, since these ATPases are dependent of ATP, as observed by Baldissera et al. [31] in fish experimentally infected by Aeromonas caviae. We observed th
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Preliminary results of studies sponsored by the manufacturer
2024-07-17
Preliminary results of studies sponsored by the manufacturer of ETC-1002 have also shown positive results for monotherapy in statin-intolerant patients and for the combined use of the ACL inhibitor plus other cholesterol-reducing agents. In patients with a documented history of intolerance to statin
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ASK has been identified as an ASK binding protein
2024-07-17
ASK2 has been identified as an ASK1 binding protein (Wang et al., 1998). ASK1 supports the stability and active configuration of ASK2 in the heteromeric complex, while ASK2 has been found to activate ASK1 by direct phosphorylation (Takeda et al., 2007). Unlike ASK1, which is ubiquitously expressed i
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According to the present observations the Ampk
2024-07-17
According to the present observations, the Ampkα1 isoform promotes AP-1 transcriptional activity and thereby fosters DL-AP5 Sodium salt receptor of AP-1 target genes in cardiomyocytes via activation of Pkcζ. The transcription factor AP-1 plays a decisive role during cardiac remodeling [24], [25], [2
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br Conclusion br References and recommended
2024-07-17
Conclusion References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Acknowledgements Introduction Nucleosome, the basic chromatin unit, is composed of DNA and core histones (H2A, H2B, H3 and H4) and organized into
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There are increasing repeated reports of amphotericin B
2024-07-17
There are increasing repeated reports of amphotericin B-resistance in pathogenic fungi including Candida spp. [35], [36]. Nolte et al. characterized some fluconazole and amphotericin B-resistant Candida albicans isolates from leukemia patients [37]. Fan-Havard et al. (1991) have shown multi-antifung
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Plant defensins Vriens et al and linear
2024-07-17
Plant defensins (Vriens et al., 2014) and linear AMPs (Domingues et al., 2015, Liu et al., 2008) have been shown to present several modes of action. Among these different mechanisms, permeabilization of the fungal membrane has been described as a secondary effect of plant defensin action (Vriens et
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Most clinically approved antiangiogenic drugs are aimed at b
2024-07-17
Most clinically approved antiangiogenic drugs are aimed at blocking the action of vascular endothelial growth factor, or VEGF, which is accepted to be the most important tumor-derived angiogenic factor, stimulating proliferation and migration of endothelial cells, as well as branching of vessels (Fe
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The increased occurrence of ARIA
2024-07-17
The increased occurrence of ARIA-E in APOE ε4 carriers in phase 2 studies resulted in separate protocols for carriers and noncarriers in the subsequent phase 3 studies. Two 18-month trials comprising 1121 carriers and 1331 noncarriers with mild to moderate AD tested doses of bapineuzumab that varied
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However in recent years advanced experiments and
2024-07-17
However, in recent years advanced experiments and findings are emerging to give us more detailed information on Aβ-membrane interactions. Several reviews have provided background on the fibrillation of Aβ and the Aβ-membrane interactions [[18], [19], [20], [21], [22]]. In this review, we mainly focu
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A candidate protein for the regulation of AMPAR
2024-07-17
A candidate protein for the regulation of AMPAR transport is CaMKII, a Ca2+-dependent kinase with diverse cellular functions. With respect to synaptic transmission, CaMKII is recognized as a key synaptic protein that is required to modify the number of synaptic AMPARs in response to LTP and LTD stim
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and LO are members of the lipoxygenase family that convert
2024-07-17
5- and 12/15-LO are members of the lipoxygenase family that convert arachidonic Dig-11-utp into lipid mediators such as leukotriene B4 (LTB) and 12()-hydroxyeicosatetraenoic acid (HETE) and 15()-HETE, respectively. Evidence from several in vitro and in vivo studies has shown that activation of the 5
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