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br Introduction Histamine stored in
2022-08-08
Introduction Histamine stored in mast cells and basophils has been recognized as one of the most critical mediators in allergic reactions and plays an important role in eliciting the nasal symptoms of allergic rhinitis, such as sneezing, nasal itch, pain, rhinorrhea, and congestion [1], [2]. It i
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br Obesity tips to a systematic failure
2022-08-08
Obesity tips to a systematic failure in the overall metabolic regulation; it is a major global health problem and is linked to several metabolic diseases such as (T2D) (see ), (NAFLD), and cardiovascular disorders. The prevalence of such metabolic disorders has increased dramatically worldwide ,
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br Materials and methods br
2022-08-05
Materials and methods Results Discussions The treated tannery effluent (both MF and MF+RO treated) was free from most of the organic and inorganic loadings as reflected from the values of COD, BOD, total kjeldahl nitrogen (TKN) and sulfides etc. Toxicity study of the effluent (both treated
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Cells undergoing EMT display a
2022-08-05
Cells undergoing EMT display a downregulation of E-cadherin and dissociation of their junctional complexes that associates cell-cell contacts with the 2-D08 cytoskeleton, known as the adherens junction (Berx and van Roy, 2009, Birchmeier and Behrens, 1994). Adherens junctions are specialized cell-c
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To date very little is known about
2022-08-05
To date, very little is known about the GEFs that regulate RhoA during amoeboid migration. GEF-H1, a RhoA GEF, is activated response to microtubule destabilization and promotes amoeboid migration (Eitaki, Yamamori, Meike, Yasui, & Inanami, 2012). Interestingly, the majority of Paeonol synthesis depl
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Initial evidence that cell contact
2022-08-05
Initial evidence that cell-contact-mediated transmission of HIV-1 is relevant for the generation of latently infected BMS-626529 was suggested in the context of transmission from dendritic cells to resting CD4+ T cells (Evans et al., 2013, Kumar et al., 2015). As dendritic cells probe for antigens,
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Obestatin increased GnRH mRNA expression
2022-08-05
Obestatin increased GnRH mRNA expression in the POA, being the main place of GnRH synthesis (Goodman, 2015). Simultaneously, obestatin also caused a decrease in the GnRH mRNA expression in ME, without affecting the level of this peptide mRNA in AHA. A lack of differences observed in the mRNA level i
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br Flavonoid function Antioxidants are compounds when presen
2022-08-05
Flavonoid function Antioxidants are compounds - when present at a lower concentration compared oxidizable substrate - that delay or prevent oxidation of the substrate [14], [106]. Antioxidants act as nucleophiles to reduce an oxidative molecule to prevent its interaction with another molecule [14
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Previously we have shown that the natural flavonoid compound
2022-08-05
Previously, we have shown that the natural flavonoid compounds that possess C-4 ketone group and C-5 hydroxy group, such as baicalein, luteolin, myricetin and quercetin, effectively inhibit human GLO I. Considering our interest in inhibitors of GLO I and based on the rationale mentioned above, struc
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Up to now many UDG assays have
2022-08-05
Up to now, many UDG assays have been reported based on the design of dU-containing substrate DNA, which can be roughly divided into two categories according to the sensing mechanisms. One type of UDG assays are simply based on the physical or chemical property changes of the substrate accompanied wi
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By contrast pentameric glycine receptors GlyR in humans
2022-08-05
By contrast, pentameric glycine receptors (GlyR) in humans have four functional subunits, α1− α3 and β (Lynch, 2004) whereas the retina of other mammals have an additional α4 subunit (Harvey et al., 2000), and in humans the α4 subunit is considered a pseudogene as it lacks the 4th transmembrane doma
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br Inclusion exclusion criteria br Quality assessment All st
2022-08-05
Inclusion/exclusion criteria Quality assessment All studies included in the qualitative synthesis were evaluated using the Quality Assessment Tool for Quantitative Studies (QATQS), which allows to determine their methodological quality. QATQS assesses 8 sections: selection bias, study design,
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DNAzymes a series of nucleotide
2022-08-05
DNAzymes, a series of nucleotide sequences with specific catalytic activity, have been reported frequently applied in detection assays for such as ions and amino acids, due to the advantage in stability, high cost-effectiveness and modification convenience, by comparison with protein enzymes. The DN
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In the upper part of the intestine a small
2022-08-04
In the upper part of the intestine a small amount of conjugated BAs are reabsorbed via passive diffusion, whereas the part of BAs that escape enterohepatic circulation passes into the colon where they undergo bacterial conversions such as deconjugation, dehydroxylation or dehydrogenation, into secon
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In order to establish proper
2022-08-04
In order to establish proper folding and enzymatic activity, G9a and GLP methyltransferases each contain four structural zinc ions. Both open a bun shop contain two distinguishable types of zinc fingers; three Zn(II) ions are chelated in a triangular cluster by 9 cysteines (b, top left), whereas one
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