• The instructive precedent for galectin phosphorylation is hu

  2021-03-12

  

  The instructive precedent for galectin phosphorylation is human galectin-3 (hGal-3). Its serine modification by protein kinase CK1 in the N-terminal tail is relevant for nuclear export during the course of apoptosis regulation and contact formation with the neural cell adhesion molecule L1 , , , . T

• HA activates its receptor channels to cause an inward chlori

  2021-03-12

  

  HA activates its receptor channels to cause an inward chloride flux in the insect nervous system (Hardie, 1989). Two genes encoding the subunits of these channels were first identified in D. melanogaster: one previously known as ort (also differently named as hclA, DM-HisCl-α1, hisCl2 and Dm HA-Cl I

• Fluconazole Immune modulation by steroid hormones is a

  2021-03-12

  

  Immune modulation by steroid hormones is a rather new aspect of the research on endocrine interactions in lower vertebrates (Harris and Bird, 2000). In the classical view, steroids exert their effects by binding to specific intracellular receptors that function as ligand-activated transcriptional re

• In brief while previous studies have evaluated the individua

  2021-03-12

  

  In brief, while previous studies have evaluated the individual roles of VDR and ER signaling pathways in breast cancer, in the present study we performed an in silico approach for comparative evaluation of these pathways. Considering the complex interaction networks in the context of cancer, such co

• br Discussion We are reporting

  2021-03-12

  

  Discussion We are reporting a cryptic insertion of chromosome 22 material (EWS) to the long arm of chromosome 11 (11q24, FLI-1) recognizable by FISH in Conoidin A exhibiting trisomy 8 as the sole cytogenetic anomaly. In ES and PNET tumors, trisomy 8 is the most common secondary abnormality [6].

• Another important consideration with respect to

  2021-03-12

  

  Another important consideration with respect to drug conditioning suggested by the present findings is the observation of an attenuated casr on the second extinction trial. Seemingly, if ERK measurements were made following a partial reduction in the conditioned response the ERK response would prese

• Initially we ascertained that if the dose of

  2021-03-12

  

  Initially, we ascertained that if the dose of elastase was sufficient to cause pulmonary emphysema, then pulmonary emphysema could be maintained throughout the study. We found that elastase at 3U was sufficient to cause emphysema that remained over 35 days. In this experimental design of lung diseas

• How does APC C recognize its substrates and

  2021-03-12

  

  How does APC/C recognize its substrates and catalyze their ubiquitylation? How are the outcomes and timing of these activities regulated? These questions have driven a decade of structural studies that begin to explain how APC/C interacts with coactivators, substrates, and E2s, and how these interac

• br Concluding remark br Acknowledgements br Detection and re

  2021-03-12

  

  Concluding remark Acknowledgements Detection and repair of the numerous, and potentially lethal, DNA lesions arising in human Nimodipine synthesis daily is largely mediated by an efficient system collectively termed the DNA-damage response (DDR). Paradoxically, DNA-repair processes within c

• br Results and discussion In the present study we used

  2021-03-12

  

  Results and discussion In the present study, we used a set of compounds (Fig. 2) consisting of ATP (a), dATP (b), an ATP analog containing β,γ-nonhydrolyzable hypophosphate P-P bond (c), and three pairs of P-diastereoisomers of α-thio-ATP analogs (d,e,f) containing a sulfur TNKS 22 instead of one

• Cell lines which possess microglial or neuronal properties a

  2021-03-11

  

  Cell lines which possess microglial or neuronal properties are uncomplicated and convenient in vitro models for studying 3-Deazaadenosine injury at the cellular and molecular levels. Microglial BV-2 cells are derived from the immortalized mouse microglia and exhibit many of the morphological, pheno

• OICR-9429 We hypothesized that the atopic phenotype

  2021-03-11

  

  We hypothesized that the atopic phenotype may be partially influenced by an altered binding and/or signalling due to the amino-acid substitution in the receptor protein. The principal aim of this study was to investigate the signalling mechanisms of the variants CysLT1-G300S and CysLT1-I206S induced

• After repeated intermittent exposure to a psychostimulant an

  2021-03-11

  

  After repeated, intermittent exposure to a psychostimulant an augmentation of drug response to motor activity is commonly observed, a phenomenon known as behavioral sensitization (Kalivas and Stewart, 1991, Steketee and Kalivas, 2011). On the other hand, several reports have pointed out that stress

• Cancer has been linked to both genetic and epigenetic

  2021-03-11

  

  Cancer has been linked to both genetic and epigenetic changes. Epigenetic modifications, mainly DNA methylation at CpG dinucleotides, affect the regulation of gene transcription without altering the gene's sequence. Short sequences rich in CpG dinucleotides (i.e., CpG islands) are often found in the

• Depending on the needs of

  2021-03-11

  

  Depending on the needs of the product to be preserved, there are several levels of barrier packaging. Usually they are classified into low and high barriers. High barriers have a low oxygen transmittal rate, low moisture vapor transmission rate, and a high tensile strength, or puncture resistance. W

15300 records 668/1020 page Previous Next First page 上5页 666667668669670 下5页 Last page